• Depo contains a hormone, called progestin, similar to the one your body makes. While you use Depo, it stops your ovaries from releasing eggs. Without an egg, you cannot get pregnant. • No method of birth control works 100%. 4 in 100 people using Depo for a year get pregnant. HOW DO I USE DEPO? Depo-Provera is used to prevent pregnancy and manage medical conditions linked to the menstrual cycle. A healthcare professional might suggest Depo-Provera if: You don't want to take a birth control pill every day. You can't or don't want to use estrogen. Medroxyprogesterone acetate (Depo-Provera, Depo-SubQ Provera) is a progestin-only birth control. It's injected into the muscles or under the skin once every 3 months by a healthcare provider to prevent pregnancy. It's also used to treat pain related to endometriosis. The Depo-Provera shot is a highly effective and low-maintenance contraceptive option, requiring only four injections per year. However, potential side effects like irregular bleeding and bone density loss are important considerations before use. Access information designed for healthcare professionals, including details about Pfizer medicines and patient support materials. Pfizer RxPathways connects eligible patients to a range of assistance programs that offer insurance support, co-pay help, and medicines for free or at a savings. DMPA is reversible and can be used by patients of all ages, including adolescents. DMPA does not protect against STIs, including HIV infection, and patients using DMPA should be counseled that consistent and correct use of external (male) latex condoms reduces the risk for STIs, including HIV infection. [31]. 4 Times a Year Long-acting, Reversible. Depo-Provera Perpetual Calendar. !1999!Pharmacia!&!Upjohn!Company8379-12 USX!2712 February!1999. Contraindicated in patients with known or suspected pregnancy or with undiagnosed vaginal bleeding. Please see accompanying full prescribing information. Depo-Provera is used as contraception to prevent pregnancy. It is also used to reduce pain cause by endometriosis. Learn about side effects, interactions and indications. Commonly referred to as the “birth control shot,” Depo-Provera® is an injectable form of birth control. It’s a shot of progestin that you get every three months, most commonly in your arm or butt. INDICATIONS AND USAGE Depo-Provera CI is indicated for use by females of reproductive potential to prevent pregnancy.